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101.
Peri Subrahmanya Srinivas Deepak Kumar Mishra Raghvendra Gupta Jose Martin Korath Amiya Kumar Jana 《Canadian Metallurgical Quarterly》2019,58(3):308-324
In continuous slab casting, clogging in the submerged entry nozzle (SEN) ports leads to flow asymmetry and vortex formation in the mould. Knowledge of vortexing and its influence on product quality is fundamental for defect-free production. In this study, the interconnected effects of nozzle clogging and SEN submergence depth, variation on flow asymmetry and vortex characteristics in a 0.4 scale water caster have been characterised by CFD investigation and validated with experimental results from the authors’ previous work. Mean flow velocities at the sub-meniscus and near the port exit predicted by the computational model are compared with the time-averaged values of the impeller probe velocity measurements and found to be in reasonable agreement. Three different clogging conditions (0, 33 and 66% in the left port of the SEN) for SEN submergence depth of 60?mm are studied and the 66% clogging produced vortices having largest diameter, which is consistent with the experimental observations. The effects of SEN submergence depth on flow asymmetry and vortexing are investigated with three different conditions – 40, 60 and 80?mm. It is found that the shallow SEN submergence depth (40?mm) produces vortices of largest diameter and the flow is most stable for a SEN submergence depth of 60?mm among the three cases. Vortex bending towards the SEN as noticed in the experimental observations is also observed in the computational study. This work illustrates the possibility of capturing features of vortexing using validated CFD model. 相似文献
102.
Gupta Sujit Kumar Ashwin T. S. Guddeti Ram Mohana Reddy 《Multimedia Tools and Applications》2019,78(18):25321-25348
Multimedia Tools and Applications - In the era of the smart classroom environment, students’ affective content analysis plays a vital role as it helps to foster the affective states that are... 相似文献
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In this paper we investigate information-theoretic image coding techniques that assign longer codes to improbable, imprecise and non-distinct intensities in the image. The variable length coding techniques when applied to cropped facial images of subjects with different facial expressions, highlight the set of low probability intensities that characterize the facial expression such as the creases in the forehead, the widening of the eyes and the opening and closing of the mouth. A new coding scheme based on maximum entropy partitioning is proposed in our work, particularly to identify the improbable intensities related to different emotions. The improbable intensities when used as a mask decode the facial expression correctly, providing an effective platform for future emotion categorization experiments. 相似文献
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Dr. Richa Sharma Tulika Srivastava Alka Raj Pandey Dr. Tripti Mishra Dr. Bhagyashri Gupta Dr. Sabbu Sathish Reddy Dr. Suriya P. Singh Dr. Tadigoppula Narender Aradhya Tripathi Dr. Balasubramanian Chandramouli Dr. Koneni V. Sashidhara Dr. Smriti Priya Dr. Niti Kumar 《ChemMedChem》2021,16(13):2146-2156
Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small-molecule modulators or structural-correctors for conformationally destabilized proteins implicated in various protein aggregation diseases. Using a metastable-reporter-based primary screen, we evaluated pharmacological chaperone activity of a diverse class of natural products. We found that a flavonoid glycoside ( C-10 , chrysoeriol-7-O-β-D-glucopyranoside) stabilizes metastable proteins, prevents its aggregation, and remodels the oligomers into protease-sensitive species. Data was corroborated with additional secondary screen with disease-specific pathogenic protein. In vitro and cell-based experiments showed that C-10 inhibits α-synuclein aggregation which is implicated in synucleinopathies-related neurodegeneration. C-10 interferes in its structural transition into β-sheeted fibrils and mitigates α-synuclein aggregation-associated cytotoxic effects. Computational modeling suggests that C-10 binds to unique sites in α-synuclein which may interfere in its aggregation amplification. These findings open an avenue for comprehensive SAR development for flavonoid glycosides as pharmacological chaperones for metastable and aggregation-prone proteins implicated in protein conformational diseases. 相似文献
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Corneal collagen crosslinking (CXL) is a non invasive technique used in halting the progression of keratoconus. Complications with this modality are rare. We report a case of an 8-year-old child who developed sterile infiltrates in the immediate postoperative period after uneventful corneal collagen crosslinking for keratoconus. The infiltrates resolved with topical steroid therapy. There was also present coexisting vernal keratoconjunctivitis (VKC) which was controlled with topical 2% cyclosporine A eye drops prior to crosslinking treatment. This case highlights importance of controlling VKC prior to CXL in keratoconus as it adds to the risk of developing post operative sterile keratitis. 相似文献
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Anurag Gupta Bruce C. Kim Eugene Edwards Christina Brantley Paul Ruffin 《Materials Science and Engineering: B》2012,177(18):1583-1588
High-quality zinc oxide (ZnO) nanowires were synthesized using the atmospheric chemical vapor deposition technique and were appropriately characterized. Subsequently, the nanowire surface was covalently grafted with 1-pyrenebutyric acid (PBA) fluorophore, and surface-sensitive X-ray photoelectron spectroscopy and Fourier transform infrared-attenuated total reflectance spectroscopy were utilized to confirm the functionalization of 1-pyrenebutyric acid on the nanowire surface. Additionally, photoluminescence (PL) measurements were used to evaluate the optical behavior of pristine nanowires. Through fluorescence quenching of 1-pyrenebutyric acid by p-nitrophenol, a detection limit of 28 ppb was estimated. Based on these findings, ZnO nanowires functionalized with 1-pyrenebutyric acid are envisaged as extremely sensitive platforms for the ultra-trace detection of p-nitrophenol in biological systems. 相似文献